البحوث العلمية

<p style="text-align:center">&nbsp;</p> <p style="text-align:center"><strong><u><span style="color:#002060; font-family:&quot;Hacen Typographer Md&quot;; font-size:20.0pt">البحوث المنشورة</span></u></strong></p> <p style="text-align:left"><strong><span style="font-size:14.0pt">ORIGINAL RESEARCH ARTICLES</span></strong></p> <p style="margin-left:36pt; margin-right:0cm; text-align:left"><u>ZGAIR, A</u>., WONG, J. C., SABRI, A., FISCHER, P. M., BARRETT, D. A., CONSTANTINESCU, C. S. &amp; GERSHKOVICH, P. 2015. <a href="https://www.sciencedirect.com/science/article/abs/pii/S0731708515003052">Development of a simple and sensitive HPLC&ndash;UV method for the simultaneous determination of cannabidiol and &Delta;9-tetrahydrocannabinol in rat plasma</a>. <em>Journal of pharmaceutical and biomedical analysis,</em> 114<strong>,</strong> 145-151.</p> <p style="margin-left:36pt; margin-right:0cm; text-align:left"><u>ZGAIR, A.,</u> WONG, J. C., LEE, J. B., MISTRY, J., SIVAK, O., WASAN, K. M., HENNIG, I. M., BARRETT, D. A., CONSTANTINESCU, C. S. &amp; FISCHER, P. M. 2016. <a href="https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5009397/">Dietary fats and pharmaceutical lipid excipients increase systemic exposure to orally administered cannabis and cannabis-based medicines</a>. <em>American journal of translational research,</em> 8<strong>,</strong> 3448.</p> <p style="margin-left:36pt; margin-right:0cm; text-align:left"><u>ZGAIR, A.,</u> LEE, J. B., WONG, J. C., TAHA, D. A., ARAM, J., DI VIRGILIO, D., MCARTHUR, J. W., CHENG, Y.-K., HENNIG, I. M. &amp; BARRETT, D. A. 2017. <a href="https://www.nature.com/articles/s41598-017-15026-z">Oral administration of cannabis with lipids leads to high levels of cannabinoids in the intestinal lymphatic system and prominent immunomodulation</a>. <em>Sci Rep,</em> 7<strong>,</strong> 14542.</p> <p style="margin-left:36pt; margin-right:0cm; text-align:left">TAHA, D. A., <u>ZGAIR, A</u>., LEE, J. B., DE MOOR, C. H., BARRETT, D. A., BRUCE, K. D., SUNGELO, M., ECKEL, R. H. &amp; GERSHKOVICH, P. 2017. <a href="https://www.sciencedirect.com/science/article/abs/pii/S0928098717300301?via%3Dihub">Hyperlipidaemia alone and in combination with acidosis can increase the incidence and severity of statin-induced myotoxicity</a>. <em>European Journal of Pharmaceutical Sciences,</em> 100<strong>,</strong> 163-175.</p> <p style="margin-left:36pt; margin-right:0cm; text-align:left">LEE, J. B., <u>ZGAIR, A</u>., KIM, T. H., KIM, M. G., YOO, S. D., FISCHER, P. M. &amp; GERSHKOVICH, P. 2017. <a href="https://www.sciencedirect.com/science/article/abs/pii/S1570023216310054?via%3Dihub">Simple and sensitive HPLC-UV method for determination of bexarotene in rat plasma</a>. <em>Journal of Chromatography B,</em> 1040<strong>,</strong> 73-80.</p> <p style="margin-left:36pt; margin-right:0cm; text-align:left">LEE, J. B., <u>ZGAIR, A</u>., TAHA, D. A., ZANG, X., KAGAN, L., KIM, T. H., KIM, M. G., YUN, H.-Y., FISCHER, P. M. &amp; GERSHKOVICH, P. 2017. <a href="https://www.sciencedirect.com/science/article/abs/pii/S0939641116305264?via%3Dihub">Quantitative analysis of lab-to-lab variability in Caco-2 permeability assays</a>. <em>European Journal of Pharmaceutics and Biopharmaceutics,</em> 114<strong>,</strong> 38-42.</p> <p style="margin-left:36pt; margin-right:0cm; text-align:left">NOMAN, J. A., LAFI, M. A. &amp; <u>ZGAIR, A. </u>K. 2012. Effect of Tramadol on Ovine Ureteral Smooth Muscle Contractility: an in vitro Experimental Study.<span dir="RTL" style="font-family:&quot;Arial&quot;,sans-serif"> </span>&nbsp;<em>Anbar Medical Journal</em></p> <p style="margin-left:36pt; margin-right:0cm; text-align:left"><span style="color:#222222; font-family:&quot;Arial&quot;,sans-serif; font-size:10.0pt">LEE, J. B., <u>ZGAIR, A</u>., MALEC, J., KIM, T. H., KIM, M. G., ALI, J., ... &amp; VORONIN, G. 2018. </span><a href="https://www.sciencedirect.com/science/article/pii/S0168365918304164?via%3Dihub"><span style="font-family:&quot;Arial&quot;,sans-serif; font-size:10.0pt">Lipophilic activated ester prodrug approach for drug delivery to the intestinal lymphatic system</span></a><span style="color:#222222; font-family:&quot;Arial&quot;,sans-serif; font-size:10.0pt">.&nbsp;<em>Journal of controlled release</em>,&nbsp;<em>286</em>, 10-19.</span></p> <p style="margin-left:36pt; margin-right:0cm; text-align:left"><span style="color:#222222; font-family:&quot;Arial&quot;,sans-serif; font-size:10.0pt">ALI, J., <u>ZGAIR, A</u>., HAMEED, G. S., GARNETT, M. C., ROBERTS, C. J., BURLEY, J. C., &amp; GERSHKOVICH, P. 2019. </span><a href="https://www.sciencedirect.com/science/article/pii/S0378517318308755?via%3Dihub"><span style="font-family:&quot;Arial&quot;,sans-serif; font-size:10.0pt">Application of biorelevant saliva-based dissolution for optimisation of orally disintegrating formulations of felodipine</span></a><span style="color:#222222; font-family:&quot;Arial&quot;,sans-serif; font-size:10.0pt">.&nbsp;<em>International journal of pharmaceutics</em>,&nbsp;<em>555</em>, 228-236.</span></p> <p style="margin-left:36pt; margin-right:0cm; text-align:left"><span style="color:#222222; font-family:&quot;Arial&quot;,sans-serif; font-size:10.0pt">LEE, J. B., KIM, T. H., FENG, W., CHOI, H. G., <u>ZGAIR, A.</u>, SHIN, S., ... &amp; SHIN, B. S. 2019. </span><a href="https://jpharmsci.org/article/S0022-3549(18)30553-7/fulltext"><span style="font-family:&quot;Arial&quot;,sans-serif; font-size:10.0pt">Quantitative Prediction of Oral Bioavailability of a Lipophilic Antineoplastic Drug Bexarotene Administered in Lipidic Formulation Using a Combined In Vitro Lipolysis/Microsomal Metabolism Approach</span></a><span style="color:#222222; font-family:&quot;Arial&quot;,sans-serif; font-size:10.0pt">.&nbsp;<em>Journal of pharmaceutical sciences</em>,&nbsp;<em>108</em>(2), 1047-1052.</span></p> <p style="margin-left:36pt; margin-right:0cm; text-align:left"><span style="color:#222222; font-family:&quot;Arial&quot;,sans-serif; font-size:10.0pt">LEE, J. B., RADHI, M., CIPOLLA, E., GANDHI, R. D., SARMAD, S., <u>ZGAIR, A.</u>, ... &amp; ORTORI, C. A. 2019. </span><a href="https://www.nature.com/articles/s41598-019-52254-x"><span style="font-family:&quot;Arial&quot;,sans-serif; font-size:10.0pt">A novel nucleoside rescue metabolic pathway may be responsible for therapeutic effect of orally administered cordycepin</span></a><span style="color:#222222; font-family:&quot;Arial&quot;,sans-serif; font-size:10.0pt">.&nbsp;<em>Scientific reports</em>,&nbsp;<em>9</em>(1), 1-12.</span></p> <p style="margin-left:36pt; margin-right:0cm; text-align:left"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><u><span style="font-size:10.0pt"><span style="font-family:&quot;Arial&quot;,sans-serif"><span style="color:#222222">ZGAIR A</span></span></span></u><span style="font-size:10.0pt"><span style="font-family:&quot;Arial&quot;,sans-serif"><span style="color:#222222">, DAWOOD Y, IBRAHEM SM, BACK HM, KAGAN L, GERSHKOVICH P, LEE JB. <a href="https://www.mdpi.com/2076-3417/10/20/7283" style="color:#0563c1; text-decoration:underline">Predicting Intestinal and Hepatic First-Pass Metabolism of Orally Administered Testosterone Undecanoate</a>. <em>Applied Sciences</em>. 2020 Jan;10(20):7283.</span></span></span></span></span></p> <p style="text-align:left"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><span style="font-size:10.0pt"><span style="font-family:&quot;Arial&quot;,sans-serif"><span style="color:#222222">QIN C, CHU Y, FENG W, FROMONT C, HE S, ALI J, LEE JB, <u>ZGAIR A</u>, BERTON M, BETTONTE S, LIU R. <a href="https://www.sciencedirect.com/science/article/abs/pii/S0168365920306143" style="color:#0563c1; text-decoration:underline">Targeted delivery of lopinavir to HIV reservoirs in the mesenteric lymphatic system by lipophilic ester prodrug approach</a>. <em>Journal of Controlled Release</em>. 2021 Jan 10;329:1077-89.</span></span></span></span></span></p> <p style="text-align:left"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><u><span style="font-size:10.0pt"><span style="font-family:&quot;Arial&quot;,sans-serif"><span style="color:#222222">ZGAIR A</span></span></span></u><span style="font-size:10.0pt"><span style="font-family:&quot;Arial&quot;,sans-serif"><span style="color:#222222">, DAWOOD Y, IBRAHEM SM, LEE JB, FENG W, FISCHER PM, GERSHKOVICH P. <a href="https://www.mdpi.com/1420-3049/26/1/233" style="color:#0563c1; text-decoration:underline">Strawberry Decreases Intraluminal and Intestinal Wall Hydrolysis of Testosterone Undecanoate</a>. <em>Molecules</em>. 2021 Jan;26(1):233.</span></span></span></span></span></p> <p style="text-align:left"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><span style="font-size:10.0pt"><span style="font-family:&quot;Arial&quot;,sans-serif"><span style="color:#222222">FENG W, QIN C, CHU Y, BERTON M, LEE JB, <u>ZGAIR A</u>, BETTONTE S, STOCKS MJ, CONSTANTINESCU CS, BARRETT DA, FISCHER PM. <a href="https://www.sciencedirect.com/science/article/abs/pii/S0939641121000576" style="color:#0563c1; text-decoration:underline">Natural sesame oil is superior to pre-digested lipid formulations and purified triglycerides in promoting the intestinal lymphatic transport and systemic bioavailability of cannabidiol</a>. <em>European Journal of Pharmaceutics and Biopharmaceutics</em>. 2021 May 1;162:43-9.</span></span></span></span></span></p> <p style="text-align:left"><span style="font-size:11pt"><span style="font-family:Calibri,sans-serif"><span style="font-size:10.0pt"><span style="font-family:&quot;Arial&quot;,sans-serif"><span style="color:#222222">RASHID RA, <u>ZGAIR A</u>, AL-ANI RM. <a href="https://www.sciencedirect.com/science/article/pii/S0196070921001344" style="color:#0563c1; text-decoration:underline">Effect of nasal corticosteroid in the treatment of anosmia due to COVID-19: A randomised double-blind placebo-controlled study</a>. American Journal of Otolaryngology. 2021 Sep 1;42(5):103033.</span></span></span></span></span></p> <p style="margin-left:36pt; margin-right:0cm; text-align:left"><span style="font-size:10.0pt"><span style="font-family:&quot;Arial&quot;,sans-serif"><span style="color:#222222">LEE JB, ZANG X, <u>ZGAIR A</u>, OOI TQ, FOLEY DW, VORONIN G, KAGAN L, SOUKARIEH F, GAO R, SHAO H, SOH WT. <a href="https://www.sciencedirect.com/science/article/abs/pii/S0939641121001302" style="color:#0563c1; text-decoration:underline">Postprandial administration but not controlled release in the colon increases oral bioavailability of DF030263, a promising drug candidate for chronic lymphocytic leukemia</a>. European Journal of Pharmaceutics and Biopharmaceutics. 2021 May 12.</span></span></span></p> <p style="margin-left:36pt; margin-right:0cm; text-align:left"><span style="color:#222222; font-family:&quot;Arial&quot;,sans-serif; font-size:10.0pt">&nbsp;</span></p> <p style="text-align:left"><strong><span style="font-size:14.0pt">BOOK CHAPTER</span></strong></p> <p style="margin-left:36pt; text-align:left"><u>ZGAIR, A</u>., WONG, J. C. M. &amp; GERSHKOVICH, P. 2016b. <a href="https://link.springer.com/chapter/10.1007/978-3-319-28609-9_14">Targeting Immunomodulatory Agents to the Gut-Associated Lymphoid Tissue</a>. <em>Neuro-Immuno-Gastroenterology.</em> Springer, Cham.</p> <p>&nbsp;</p>

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